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Date: Dec 16, 2013

Hofstra North Shore-LIJ School of Medicine Student - Brian Dulmovits

Awarded the American Society of Hematology’s Physician-Scientist Career Development Grant




Hofstra University, Hempstead, NY…Brian Dulmovits, a second-year student at the Hofstra North Shore—LIJ School of Medicine, was awarded the American Society of Hematology’s Physician-Scientist Career Development Award under the joint mentorship of Jeffrey Lipton, MD, PhD and Lionel Blanc, PhD.

During his first semester of Medical School, Brian met Dr. Lipton while learning cancer biology through the lens of hematologic malignancy in The Biologic Imperative course, which Dr. Lipton co-directs. Soon afterward, Brian began planning and working with Dr. Lipton and Dr. Blanc in anticipation of an extended summer research project, which earned funding from the St. Baldrick’s Foundation.

The American Society of Hematology’s Physician-Scientist Career Development Award will provide Brian year-long laboratory research experience under the co-mentorship of Jeffrey Lipton and Lionel Blanc at the Feinstein Institute for Medical Research, Cohen Children’s Medical Center of New York and the Hofstra North Shore-LIJ School of Medicine. This award allows Brian to focus on understanding red cell biology and erythropoiesis and apply these principles to the field of hemoglobinopathies and hematological research through his sickle cell anemia project.

Brian’s research focuses on the treatment of sickle cell disease. Sickle cell disease (or SCD) relies on stimulation of fetal hemoglobin production. Hydroxyurea, the mainstay and only FDA-approved SCD therapy, has been shown to increase circulating fetal hemoglobin levels. Unfortunately, hydroxyurea carries harmful and dose-limiting side effects such as myelosuppression, and as many as 30% of patients fail to respond to hydroxyurea. Therefore, new therapeutics must be developed to expand current treatment options for SCD.

Brian’s funded research will further investigate the molecular mechanisms that underlie increased fetal hemoglobin production. Preliminary data from the laboratory has shown that these drugs target important regulators of globin gene synthesis.

Brian has articulated a deep and steadfast commitment to an investigative career in translational hematology research; his choices and actions to this point have demonstrated his intent to translate that commitment into reality.

Dr. Lipton is the Head of Patient-Oriented Research at the North Shore-LIJ Feinstein Institute for Medical Research and the Chief of Hematology/Oncology and Stem Cell Transplantation at the Cohen Children’s Medical Center of New York. Dr. Lipton is also a Professor of Molecular Medicine at the Hofstra North Shore-LIJ School of Medicine, where he has been an active member and vibrant leader. Dr. Blanc is an Assistant Investigator at the Center for Oncology and Cell Biology, Laboratory of Developmental Erythropoiesis at the North Shore-LIJ Feinstein Institute for Medical Research and also serves as an Assistant Professor of Molecular Medicine and Pediatrics at the Hofstra North Shore-LIJ School of Medicine. Thus, Brian has been and will continue to be in an environment that richly supports his development as a physician-scientist.

About the Hofstra North Shore-LIJ School of Medicine

The School of Medicine was formed in response to the Association of American Medical Colleges’ 2006 recommendation to increase medical school enrollment by 30 percent by 2015. Hofstra University, Long Island’s largest and most prestigious private university, and North Shore-LIJ Health System, one of the largest health systems in the nation, responded to this need by establishing the Hofstra North Shore-LIJ School of Medicine.

The School of Medicine is built upon the strong clinical and graduate medical education programs of the Health System and the robust research and academic programs of Hofstra University and the Feinstein Institute for Medical Research at North Shore-LIJ Health System. In August 2011, the School of Medicine welcomed its inaugural class which will graduate in May 2015.

About Hofstra University

Founded in 1935 as a college affiliated with New York University (NYU), Hofstra separated from NYU in 1939 and was granted an absolute charter a year later. With the approval of the New York State Board of Regents, Hofstra became Long Island’s first private university in 1963. In 1966, the Board of Regents authorized Hofstra University to offer doctoral degrees and, in 1973, Hofstra was granted a Phi Beta Kappa charter. Today, almost 11,500 students learn from more than 500 full-time faculty members on a 240-acre campus. Hofstra faculty members are leading scholars in their disciplines. Each semester, students choose from approximately 2,000 courses within 140 undergraduate and 150 graduate programs.

In addition to the School of Medicine, the following schools comprise Hofstra University: the College of Liberal Arts and Sciences, Frank G. Zarb School of Business, Maurice A. Deane School of Law, School of Communication, School of Education, Honors College, School of Health Sciences and Human Services, School of Engineering and Applied Sciences, and School for University Studies. Recently, the University has added programs in health professions, including Master’s programs in Public Health and Medical Physics.
The 240-acre campus of Hofstra University is a nationally recognized arboretum and a registered member of the prestigious American Public Gardens Association.

About North Shore-LIJ Health System

The nation's third-largest, non-profit, secular healthcare system, North Shore-LIJ delivers world-class clinical care throughout the New York metropolitan area, pioneering research at The Feinstein Institute for Medical Research and a visionary approach to medical education, highlighted by the Hofstra North Shore-LIJ School of Medicine. North Shore-LIJ cares for people at every stage of life at 16 hospitals, two long-term care facilities and nearly 400 outpatient physician practices throughout the region. North Shore-LIJ’s owned hospitals and long-term care facilities house more than 6,000 beds, employ more than 10,000 nurses and have affiliations with more than 9,400 physicians. With a workforce of more than 46,000, North Shore-LIJ is the largest employer on Long Island and the third-largest private employer in New York City. For more information, go to www.northshorelij.com.