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First 100 Weeks

Educaton FOW


Host-Microbe Interactions (HMI) explores the contribution of microorganisms to maintaining health and causing disease.

The course begins with an overview of the fundamentals of bacteriology, virology, mycology, and parasitology. Additional focus is placed on the role of the microbiome in maintaining human homeostasis. This is followed by a systems-based approach to covering infectious diseases. Emphasis is placed on the mechanisms by which pathogenic microbes evade the immune system and subvert normal host cellular functions. Pharmacological principles of antimicrobial therapy are covered throughout the course. HMI links to the next course, The Human Condition, by concluding with infections of the central nervous system.

  • Course Goals

    Host-Microbe Interactions: Course Goals

    1. Understand the diversity, structure, physiology, and genetics of microbes that cause infectious disease, and the molecular basis for antimicrobial therapies.
    2. Understand the processes used by microbes to evade immune recognition and subvert host defense, and the pathophysiology of important infectious diseases.
    3. Understand the importance of the human microbiome in immune function and maintaining host homeostasis.
    4. Understand how current knowledge of immunity, infection, commensal microbes, and infectious agents results in design of therapies, and how filling gaps in knowledge could contribute to advances in treatment of infectious diseases in the future.
    5. Demonstrate competence in methods used to diagnose and assess infectious disease.
    6. Understand the role of imaging modalities in the diagnosis of infectious diseases and interpret imaging studies of these systems.
    7. Develop advanced understanding of curricular drivers in relation to individual patients and populations.
    8. Develop advanced communication skills necessary to effectively develop longitudinal and therapeutic relationships with more challenging patients and health care teams.
    9. Develop diagnostic clinical reasoning skills by examining how a clinician approaches a patient's chief complaint.
    10. Continue to experience meaningful patient encounters in the context of community-based clinical practices with focus on Pediatrics. 
  • Clinical Learning Objectives
    Clinical Learning Objectives: Host-Microbe Interactions
    Runs from September to December
    A: Assist               P: Perform
    History, Communication and Clinical Reasoning Skills Physical Exam Procedures/Screens/Documentation
    Obtain a Complete History with Agenda Setting (P) Conduct a Pediatric Physical Exam (P) Document a History of Present Illness (HPI) (P)
    Obtain a History of Present Illness (HPI) (P) Conduct a Musculoskeletal Exam Document an Interval History (P)
    Obtain an Interval History (P) Administer a HEEADSSS Screen + CRAFFT
    Obtain a Sexual History (P) Document a Pediatric Physical Exam
    Generate a Differential Diagnosis (P) Identify a Screening Test for a Patient to your Preceptor using
    Educate a Patient on a New Rx (P) Use CDC Guidelines to Determine Recommended Vaccines for a Patient
    Obtain a Pediatric Developmental History
    Obtain a Nutrition Assessment and Provide Feedback on any Dietary Recommendations
    Provide Pediatric Anticipatory Guidance
    Demonstrate the use of a BMI Calculator for a Child
  • Assessment Methods

    Students are assessed in a variety of ways to generate a grade in the courses completed in the First 100 Weeks. As a faculty member or resident who is responsible for supervising a student, you will be expected to complete one or more assessment forms. The questions/anchors can be found on the First 100 Weeks Assessment page

Typical Week of Study